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North Macedonia 0-2 Scotland: Kieron Bowie and a John McGinn penalty earned Sebastien Pocognoli his first win in charge, despite a late red card for Scott McKenna.
Spain 3-1 Czechia: Lamine Yamal, Rodri and Mikel Merino scored as the world champions beat ten-man Czechia in Oviedo to stay top of Nations League Group A3.
Croatia 0-7 England: Harry Kane and Bukayo Saka scored twice each as Thomas Tuchel's side ran riot in Rijeka to go level with Spain in Nations League Group A3.
North Macedonia v Scotland preview: Sebastien Pocognoli's side need a goal and a first win in Skopje, with Jack Hendry suspended.
Croatia v England in Rijeka is a fight for second place in Nations League Group C, with Thomas Tuchel warning his players against complacency.
Sweden, top of Nations League B Group D, travel to second-placed Bosnia without Isak and five players struck by illness.
Ukraine and Northern Ireland meet in Trnava level on four points at the top of Nations League B Group B.
Belgium host winless Türkiye in Liège looking to bounce back from defeat by France. Team news, form, head-to-head and kick-off time.
Unbeaten France host Italy at the Stade de France with Group A leadership at stake. Team news, form, head-to-head and kick-off time.
Rasmus Hojlund copied Cristiano Ronaldo's celebration and brushed past Jorge Jesus at full-time as Portugal won 4-2 in Copenhagen to stay perfect in the Nations League.